Bladder Cancer Breakthrough Offers New Hope For Treatment Of Patients

A breakthrough in the understanding of how bladder cancer spreads could offer new hope to patients.

Of the 10,000 people diagnosed with the disease each year in the UK, some develop invasive bladder cancer - where cancer grows through the muscle layer of the bladder.

When this occurs, there is a higher risk that the cancer will spread to other areas of the body and the disease becomes much more difficult to treat.

Until now the signalling process that allows a benign, small polyp to develop into something that spreads and is invasive has not been clear. But research carried out by a team at Plymouth University has for the first identified an important mechanism behind this process.

Key to the research is a protein, pancreatic secretory trypsin inhibitor (PSTI), which is present in most bladder cancers. The research has identified the role PSTI plays in the signalling process that allows the spread and invasion of bladder cancer.

By understanding the process by which this protein helps the cells to spread, and invade into other tissue, researchers can start to develop ways to interrupt this process, potentially leading to new treatments.

This has the potential to improve the survival and life quality of those with early diagnosed bladder cancer, and reduce the instances where rigorous drug regimes or invasive surgery are required.

See Also:

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The research was led by Professor Raymond Playford and Dr. Tanya Marchbank from Plymouth University. Professor Playford said: "Although bladder cancer can be readily treated if caught early enough, once it starts to invade into deeper tissues and spread to distant sites it is a much more difficult, painful and life-affecting cancer to live with.

"Treatment becomes more difficult as tumours grow deeper into the bladder wall and spread, and survival rates decline ? it is estimated that just 25 per cent of those with severe invasive bladder cancer will be alive and well three years after diagnosis and treatment.

"By identifying the mechanism by which bladder cancer develops and spreads, we hope that in time therapies that manipulate this mechanism may be developed to improve the quality of life and survival rates of those with invasive bladder cancer."

The research is published today 1st August 2013 in the American Journal of Physiology ? Renal Physiology.

Earlier on HuffPost:

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Source: http://www.huffingtonpost.co.uk/2013/08/01/bladder-cancer-treatment-protein-hope-patients_n_3688032.html

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The Inside Story of the Moto X: The Reason Google Bought Motorola

Two years ago, Google announced its purchase of Motorola Mobility for $12.5 billion, a purchase that seemed baffling. What was Google thinking? Now that we've seen the Moto X, that question has been answered.

Source: http://feedproxy.google.com/~r/GearFactor/~3/HKYSVx2iA14/

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Apple reportedly still considering Retina iPad mini for this fall

The long rumored Retina iPad mini might become reality this fall according to yet more rumors about Apple's small-sized tablet. This time the supplier-based reporting comes by way of Lorraine Luk of the Wall Street Journal:

Apple is working with suppliers in Asia on its next iPad mini with a high-resolution "retina" display, unlike the current iPad mini that comes with a lower-resolution screen, the people said. The size of the new tablet will likely be the same as the current 7.9-inch model, which was released in November last year. Apple has also been contemplating multiple color back covers for the new tablet, they said.

I've been hearing about the Retina iPad mini since January of this year. However, bringing it from prototype to production has seemingly been non-trivial, given the power demands and price-points of the components. Apple is an aggressive company - they shipped two full-sized iPads last year, after all - and it seems almost certain they'll launch a Retina iPad mini as soon as they can get the requisite amount of battery life out of it, and sell it for acceptable margins.

Color is something that makes sense as well, given Apple has historically used color to differentiate their less expensive iPods and more recently, the iPod touch, and given the rumors of colored iPhone 5C on the horizon.

Rumors of a non-Retina, yet still upgraded iPad mini may be the more conservative plan if Apple can't get the Retina mini to market in time for the holidays, or it might be a continuation of what they did with the iPad 2 when the iPad 3 went Retina - offer a new version of the old tablet at a lower price point to take even more oxygen out of the space.

Either way, it's tough to imagine Apple won't be doing something interesting with the iPad mini and soon. Which would you prefer, a cheaper standard resolution iPad mini, or a Retina iPad mini at the same or similar price?

Source: Wall Street Journal

Source: http://www.imore.com/apple-reportedly-considering-retina-ipad-mini-fall

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McCaskill introduces bill to cut red tape on infrastructure, energy projects

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Source: http://feedproxy.google.com/~r/blogspot/ASRIt/~3/Av7fCupzVS4/mccaskill-introduces-bill-to-cut-red.html

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O2 blankets London?s Canary Wharf in free Wi-Fi

The Olympics may be over, but U.K. mobile carrier O2 isn?t quite done with its project to bring free Wi-Fi access to London. The company is working with Ruckus Wireless to launch its second Wi-Fi hotzone in the U.K. capital, this one in Canary Wharf, a financial and commercial center that plays host to 100,000 people each business day.

O2?s first hotzone covered high-traffic areas in London?s high-tourism West End. It certainly wasn?t the biggest Wi-Fi project with only 100 access points (BT installed more than 1,500 access points in the city for the Olympics). But O2?s project has two notable distinctions: 1) Service is free to all comers, whether or not they are existing O2 subscribers and 2) The Wi-Fi network is serving as a blueprint for O2?s future small cells rollout.

O2 is installing Ruckus access points that can be upgraded in the future to contain cellular radios, letting the carrier boost the capacity of its 3G and future LTE networks in the same highly trafficked areas where Wi-Fi is in the most demand. That makes the Canary Wharf deployment significant. The business district isn?t just dense, home to some of London?s biggest skyscrapers and employers, but the financial financiers that make up much of its workforce are just the type of subscribers to lean heavily on mobile data.

For now, the Canary Wharf deployment seems to be Wi-Fi only. Ruckus and O2 didn?t reveal exactly how many access points would make up the hotzone, but they did promise extensive coverage. Ruckus will install both indoor and outdoor access points in Canary Wharf public areas, including four shopping malls and 20 acres of public parks and plazas. The network will automatically connect registered users to the network, while new users must complete a one-time registration process.

Source: http://gigaom.com/2013/07/31/o2-blankets-londons-canary-wharf-in-free-wi-fi/

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Keystone?s benefits to the U.S. and Canada

Gary Doer, the Canadian ambassador to the United States, was right to respond as he did to President Barack Obama?s comments on the proposed Keystone XL pipeline in the New York Times on Sunday.

Mr. Obama observed that only about 2,000 jobs would result directly from the construction of the pipeline: ?a blip relative to? the size of the American economy. The Republicans in Congress may be emphasizing the creation of jobs, but this debate is a distraction that misses the main point.

Mr. Doer emphasized the much more important argument in favour of an increase of pipeline capacity. There is a major economic benefit to both countries in relieving the pressure on North American railways to provide an increasing proportion of oil and gas shipments.

The horrific railway disaster at Lac-M?gantic, Que., is an extreme case, in which errors were evidently made , with tragic and catastrophic results. Nonetheless, it can fairly be characterized as one of the many symptoms of the larger pattern of a shortage of pipeline capacity.

Pipelines are of course imperfect, but safer (and less expensive) than railways, as carriers of oil and gas.

In March, the State Department provisionally concluded that Keystone would probably not have a substantial environment impact, and more particularly would ?not significantly exacerbate carbon pollution.? The State Department has also recognized that Canadian companies would continue to export crude oil from the oil sands, by way of a number of routes, whether or not Keystone is built.

Nonetheless, the Canadian government should be concerned that Mr. Obama may be increasingly militant on the environment in his second term, as part of the legacy he hopes to leave. In the same interview, he said: ?There is no doubt that Canada at the source in those tar sands could potentially be doing more to mitigate carbon release.? Consequently, Canada needs to make a convincing case that it is as serious as the United States about its environmental and climate-change policies.

There are alternatives to the Keystone route, but it is conveniently direct. The federal government should persist in demonstrating its mutual benefits for the United States and Canada.

Source: http://www.theglobeandmail.com/commentary/editorials/keystones-benefits-to-the-us-and-canada/article13486597/?cmpid=rss1

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U.N. promises to beef up Golan Heights contingent after Philippines threatens to withdraw its troops

The Philippines? top diplomat said Wednesday that he had reversed an earlier recommendation and now backs an international appeal for more than 300 Filipino peacekeepers to stay in the increasingly dangerous Golan Heights for six months after the United Nations promised to bolster their security.

Foreign Secretary Albert del Rosario told a news conference that U.N. officials assured him in a recent meeting in New York that they would fulfil three conditions laid down by the Philippine government, including providing the peacekeepers, who are mostly Filipino army troops, with more self-defence weapons and armour.

More Related to this Story

The Philippines has also asked the U.N. to increase the number of peacekeepers back to 1,250 as earlier agreed after a number of countries withdrew their contingents amid escalating hostilities. It also wants each batch of Filipino peacekeepers to be deployed for only six months instead of one year to allow for better assessment of security risks, del Rosario said.

Austria announced recently that it would remove its 377 peacekeepers from the 911-member U.N. peacekeeping force, which also includes troops from India who deal mostly with logistics. That left the Philippines with its 340 soldiers as the largest single contributor.

Croatia withdrew in March for fear its troops would be targeted. Japanese forces have also withdrawn.

?We said that we don?t want a situation where we?re the only ones exposed,? del Rosario said.

He said the U.N. would likely get additional troops from Fiji and Ireland and expand the current contingent back to a force of 1,250 by October.

A recent U.N. Security Council resolution sought an additional $8 million to improve security of and acquire more weapons for the peacekeepers, but wanted them to have a one-year deployment. The one-year deployment, however, is to be enforced starting in 2015, so U.N. officials could still allow Filipinos to be replaced every six months before then, del Rosario said.

Del Rosario asked President Benigno Aquino III in May to withdraw the Filipino peacekeepers from Golan due to escalating hostilities between Syrian rebels and government troops in the U.N.-patrolled buffer zone that separates Syria from the Israeli-occupied plateau.

His recommendation followed two separate abductions of Filipino peacekeepers and the wounding of another in fighting in recent months between Syrian government and rebel forces.

U.N. Secretary-General Ban Ki-moon, U.S. Secretary of State John Kerry and other governments then appealed to the Philippines to reconsider the planned withdrawal, warning of ?maximum volatility? in Golan after a number of countries decided to withdraw their peacekeeping forces.

?We received many calls from the (U.N.) secretary-general and from various other countries that our leaving would probably create a situation where there will be maximum volatility,? Del Rosario said.

After U.N. officials agreed to the Philippine conditions, del Rosario said he asked Aquino to allow the Filipinos to stay in the Golan for at least six months beyond Aug. 11, when they have to be replaced by a fresh batch. He said Aquino would likely approve the plan.

Aquino has said the changes he was looking for included additional equipment and enhanced security for the peacekeepers, and better rules of engagement.

?If there is no change in the conditions, it might be an undoable mission and our poor troops will be in the middle of two potentially clashing forces, and they cannot defend themselves,? Aquino said.

Source: http://www.theglobeandmail.com/news/world/un-promises-to-beef-up-golan-heights-contingent-after-philippines-threatens-to-withdraw-its-troops/article13523151/?cmpid=rss1

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